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Senior Member (jccglutenfree)
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Join Date: Aug 2006
Location: Wisconsin
Posts: 1,581
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Senior Member (jccglutenfree)
Join Date: Aug 2006
Location: Wisconsin
Posts: 1,581
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Hematological manifestations of celiac disease. PMID: 16973955 Sept 2006
Quote:
Celiac disease is a common systemic disorder which can have multiple hematological manifestations. Patients with celiac disease may present to hematologists for evaluation of various hematological problems prior to receiving a diagnosis of celiac disease. Anemia secondary to malabsorption of iron, folic acid and or vitamin B12 is a common complication of celiac disease and many patients present with anemia or have anemia at the time of diagnosis. Celiac disease may also be associated with thrombocytosis, thrombocytopenia, leukopenia, venous thromboembolism, hyposplenism and IgA deficiency. Patients with celiac disease are at increased risk of being diagnosed with lymphoma, especially of the T-cell type. The risk is highest for enteropathy-type T-cell lymphoma (ETL) and B-cell lymphoma of the gut but extraintestinal lymphomas can also be seen. ETL is an aggressive disease with poor prognosis but strict adherence to a gluten free diet may prevent its occurrence.
PMID: 16973955
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Patterns and presentations of adult coeliac disease in a rural setting. PMID: 16972991 Sept 2006
Quote:
ABSTRACT: Background In recent years there has been a noticeable change in the patterns and presenting symptoms of coeliac disease. This may lead to delayed diagnosis and treatment and hence increased development of complications. Aim The aim of this audit was investigate the presenting complaints of patients diagnosed with Coeliac Disease. In addition, the prevalence of associated conditions in coeliac patients. Methods Observational retrospective cross-sectional study using the medical notes from the time of diagnosis of 32 adult patients attending the specialist coeliac clinic. Results The main presenting complaint was anaemia at (21 patients, 66%). Less than half of the patients had any of the classical symptoms of coeliac disease and 8 patients (25%) had no classical symptoms at all. Biopsy was 97% sensitive, with Anti-gliadin antibodies, Anti-endomysial antibody and anti-tissue transglutaminase showing 75%, 68% and 90% sensitivity respectively. In combination, serology results were 100% sensitive. Fifty nine percent had developed osteoporosis or osteopenia. There were no malignant complications among the group. Conclusion The majority of patients did not present with diarrhoea and weight loss, the commonest presentation being with.
PMID: 16972991
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[Role of allergy in irritable bowel syndrome] PMID: 16898627 Aug 2006
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Preliminary studies have noted a possible association between IBS and allergic disorders. An increased prevalence of bronchial hyper-responsiveness in IBS has been reported. Moreover, foods are thought to often play a role in the diarrhea type IBS particularly in patients with atopic dermatitis. More than 50% of diarrhea type IBS patients have a history of allergies to some food and positive skin prick tests. Surveys indicate that as many as 20-30 % of adults have some problems to foods, however, careful studies have suggested a range from <1% to 7.5%. A systematic review of the literature concluded that it is still unclear whether diet is a key factor in exacerbating IBS symptoms and whether dietary manipulation is a valid treatment. The further studies are needed to evaluate the association between IBS and allergic disorders.
PMID: 16898627
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