One of the key foundations underlying PD is an overly zealous immune response in the brain. <Pause to inform the new faces that everything that I post has an implied IMHO attached.
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As a result of that response, infection anywhere in the body causes a flareup in the brain that does two things: it kills neurons and it puts neuroactive chemicals into the soup that disrupts everything else.
Read all about it in mind numbing detail on my blog
here.