Thanks B2Y and Sally. It took him years to make this decision so it was well thought out. And it's not the end all either. If in a year his MRI shows active lesions, then he'll be more than happy to go back on it. For now, we'll wait and see. Maybe by then research will have found something better. He's taken these shots since 1988 and still ended up in the wheelchair so who knows? He's SPMS and flairs never come anymore. Seems the shots are best suited for those who have frequent flairs and it helps slow the progression. Guess he's doing his own study.