Okay, one 500 mg dose yesterday afternoon, and one this morning. The good news... when I take that dose, I feel great! I went from leg drag with one foot barely in front of the other to a fuller stride with only my heel clipping the ground. Tremor in hand and foot are barely perceptable. The bad news... this effect only lasts as long as the rest of my meds... and 500 mg rapid release I think is too much at one time in combo with anticholinergic, Azilect, and Mirapex in the cocktail. I'm going to look for a bottle with a smaller dosage. Maybe 250 mg per dose. I will say I noticed some aching in wrist, pinkie finger and cramping in foot.