L-tyrosine, how I love thee. I will say for sure that 250 mg of this does about squat. The 500 mg seems to be the lowest effective dose. Since I was at work, I took 2 doses today. I don't feel like my face is trying to slide off, which is good since that was a concern before. I'm still walking with a normal stride and a slight heel drag on my right heel. I still had off time, so it's no better than L-dopa in that regard. The main thing is I was able to do my job at the level I was doing it just after my tremors started. Hand and foot tremors are still minimal. Anyone who doesn't know I have PD would have a hard time seeing it. I did see a big warning upon my looking up interactions, so I will pass it on. Do not use this supplement if you are already taking L-dopa. I'm still going to take it to hold me off until my neuro starts me on Sinemet. I will, however, stop taking it 2 days prior to my next appt, just until I know what the next step will be med-wise.