"NP002 is a small molecule, orally available nicotinic receptor agonist that has been shown in preclinical studies to reduce LIDs without affecting Parkinsonian symptoms."

This is a cholinergic medicine that is an agonist at the acetylcholine nicotinic receptor. It sounds to me like it would increase acetylcholine. Would someone who knows please correct me if I' m wrong...

It doesn't have to be a bad thing, but we are already over firing. So why would an excitatory drug help?

I am taking 40 mg of nortriptyline and 1.5 mg of xanax daily. low dosages of both and 2 amantadine. I am not dyskinetic unless stirred up, up late, something out of the ordinary, etc. i am much calmer now that i have given in to just spacing the meds out over the day so i'm taking something to even me out as i take sinemet every two hours. I get dyskinetic when i add any sort of dopmine agonists or comtan.