Laura
My weight has varied from 95 - 160 lbs with the same results. I am 5' 5". I have tried diet modifications - gluten free, dairy and egg free but no change.

Paula
I started on only sinemet 25/100. Tried the CR but dyskinesia got worse. It seemed to build in my system increasing dyskinesia and not giving me any longer "on time". Same with comptan. Mirapex and Requip increased my tremor so tried them for only a short time. Amantadine did nothing but give me scratchy eyes. My MDS is a believer in sinemet. He may be starting a duodopa trial that I hope to participate in. My other option is DBS. I was diagnosed 11 years ago. 6 1/2 years on sinemet. I now take 5 25/100 per day. First dose at 8:30, last dose at 5:00. Remeron and LDN at night and get a good 8 hrs of sleep with no tremor.