WOW!!!! Congrats on the good news. Some of the lesions are disappearing? That is amazing... At what infusion number did the neuro notice the shrinking lesions? I'm so happy for you--it really makes you wanna stay on this drug. . Like you I have had no new or enhancing lesions after 24 infusions. I go for 25 in two weeks. I was thinking of dropping Ty but I'm undecided. The Gilenya long term damage side effects (lung, heart, eyes) has me slightly concerned. I do love my Ty. Anyhow, happy MRI and holidays!