Remember when you hear that diagnosis of PD that there is statistically at least a 30% chance you don't have it.

Then think of those 30% participating in clinical trials for PD....not possible?!? Google the acronym SWEDDS. It stands for Subjects Without Evidence of Dopamine Deficiency. How could a participant in a PD trial, a major one looking at levodopa's role in PD progression, known as ELLDOPA have so many participants show up with a fully loaded substantia nigra? Well that's because, oops, they had primary Dystonia (have been reading on this-grossly misdiagnosed as PD). So, well, their "lucky" day. Not fun to have, but at least your brain is not endlessly attacking itself. No, the rest of us now realize that we are really screwed. Yes, so they can't even be bothered to use PET scans in research. What kind of twisted message is that?

I am sorry but why is that the FDA drones on about safety and everyone else about reliability and statistical validity? Glad l-dopa isn't harmful to people with dystonia. Anyone who ever has the gall to question alternative treatments only need to remember this.

How can they even use Placebo as an accurate measure of anything, when you can't even scientifically identify who really has PD? Let alone tell whether one has a higher endogenous reserve of dopamine than the other. I've decided the whole research "machine" runs on very little that is scientific, so maybe that should be redressed before we can say there is a placebo problem. That is the least of their worries.