This probably happens frequently with various topics but the sloppiness with which this was written is so annoying. I can tell the author is referring only to dopamine agonists being associated with ICD's. Unfortunately one has to read so carefully to not make the assumption or conclusion from what he is saying that what he refers to as DRT does not include levodopa or other forms of direct supplementation with dopamine.
Equating dopamine agonists with DRT is not at all accurate in my book.
This is particularly frustrating because having a generalized association between PWP and impulse control problems is not the most flattering one to have. Oh bother!
Quote:
Originally Posted by olsen
Addiction. 2010 Oct 6.
Impulse control disorders in patients with Parkinson's disease receiving dopamine replacement therapy: evidence and implications for the addictions field.
Ambermoon P, Carter A, Hall WD, Dissanayaka NN, O'Sullivan JD.
The University of Queensland, UQ Centre for Clinical Research, Australia The University of Melbourne...
Abstract
Aims To describe the prevalence, phenomenology and correlates of 'impulse control disorders' (ICDs) in patients with Parkinson's disease (PD) treated with dopamine replacement therapy (DRT); to assess the strength of the evidence that DRT plays a contributory causal role in these disorders; and to highlight the implications of these disorders for research in the addiction field.
Methods: PubMed and Web of Science databases were searched and the reference lists of papers examined.
Results: The prevalence of ICDs in Parkinson's patients using DRT varied between 3.5% and 13.6%, depending on the severity and range of disorders assessed. PD patients with ICDs were: generally younger; had an earlier onset of PD; had a personal or family history of substance abuse or an ICD; and were more likely to be treated with dopamine receptor agonists (DA agonists) than levodopa (l-dopa). There is reasonable evidence that dopaminergic medications play a causal role in ICDs in that they occur at a higher rate in an otherwise low-risk population of adults, begin after initiation of DA agonist therapy and cease upon its discontinuation. A causal relationship is biologically plausible, but the role of other factors (such as concurrent mood disorders) remain to be clarified by better-controlled studies. Conclusions Impulse control disorders among patients with Parkinson's disease receiving dopamine replacement therapy may provide a unique opportunity for addiction researchers to study the neurobiology of impulsive forms of behaviour (such as problem gambling) that appear to be caused, in part, by the therapeutic use of dopamine receptor agonists.
© 2010 The Authors, Addiction © 2010 Society for the Study of Addiction.
PMID: 21134016 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/2...?dopt=Abstract |