I was extra careful and rotated brilliantly. I used new areas, old areas, shot deep, shot shallow, it didnt matter. the stuff was melting the fat pad right off my thighs and bum. The MD said it was not enough to pull me off the meds because I had no other meds to go to. After a while the side effects of Copaxone caused me to set down the needle. Even with perfect skin I couldnt do it anymore.