I wondered if the BBB, blood brain barrier permeability is so important in PD, what about other neuro diseases, eg ALS, Alzheimers, MS
I came across the statement, in

http://iospress.metapress.com/(qtnbv...lts,1:105291,1

"Blood-brain barrier (BBB) disruption is one of the hallmarks of multiple sclerosis (MS)."

So if we can get anyone to take any notice of the dysfunction of the BBB in PD, we might even help the MS sufferers, ALS, Alzheimers, and who knows how many others

and
"Alterations or dysfunction of the BBB have been observed in many brain disorders", in

http://lpi.oregonstate.edu/ss03/zinc.html

Alterations or dysfunction of the BBB have been observed in many brain disorders. Free radicals may play an important role in damaging the BBB because it is especially sensitive to oxidative damage. This vulnerability may be due to the high polyunsaturated fatty acid content of the BBB membrane—fatty acids that are very susceptible to free radical attack—as well as the relatively low antioxidant capacity of the BBB. Oxidation of the membrane drastically compromises its barrier properties and may lead to subsequent brain tissue damage, resulting in a host of pathologies.

In
http://www.mult-sclerosis.org/news/D...rrierinMS.html

it states
"Increased permeability of the BBB is a feature of many diseases of the central nervous system (CNS), among them MS.3 BBB increased permeability is an early and critical event, often preceding symptoms, and, in most cases, being present in chronic lesions"

"MRI is used frequently by clinicians as a major criterion to define lesion activity, and is thought to reflect BBB damage. Although this is considered to be one of the earliest changes in observed MS lesions, neuropathological and immunocytochemical studies reveal that BBB leakage can be found to variable degrees in every MS lesion,"

Ron