Fascinating! I never started injecting until 2 weeks ago. I passed up Betaseron for MS when I read about "depression" coming from it. But now I have to inject Intron-A for another disease, Polycythemia Vera, 3 times a week. So far, no pain or dents in my abdomen. Guess it's fat enough to handle it? But I've only done it 2 weeks. I have the INtron-A to cut back number of platelets in my blood; it is not for MS.