Gosh, I didn't even think about it that I have had dry mouth during the period I've been trying a new drug, Intron-A, for Polycythemia Vera. But yes, my mouth is so dry that it's hanging open all night, and that is not usual for me. And I have lost a lot of my teeth already, so that's not good prognosis. I do use Biotene several times a day and I know it's the best mouthwash for me. However, it isn't doing much for my nighttime dry mouth. During the day it is mostly normal. I'm drinking lots of water.