Anyone experienced any kind of withdrawal symptoms after stopping Betaseron injections? I had taken Betaseron since Dx in Jan. 07 and just stopped last week DT severe injection site reactions and necrosis. Now I have to be off tx for 4 weeks befor starting new therapy. I have had a terrible headache for 5 days now, thought it was sinus headache but sinus meds not helping. Was wondering if it was related to stopping the Betaseron. Another question is I have to decide about new tx ... once a month IV infusion with Tysabri with 1 in 1000 risk of PML which is brain infection that can lead to death or severe disabilty or the new oral pill taken daily which can cause a 60% decrease in immune protection. I work in critical care setting so I'm sorda leaning towards the Tysabri. Any thought???