I use Biofreeze gel most of the time but when my feet are really on fire, I use an expensive rx called, "prudoxin" which is generic for Zonalon 5%. My podiatrist rx'd it and although it's used primarily for atopic dermatitis, it works wonderfully for PN. I try to use it sparingly since it's pricey, but worth the $$ when you're about to tear your hair out from the burning.