The anesthetics in the --caine family.... are sodium channel blocking agents. When they wear off, they may cause a rebound of pain, for a brief time. This is most noticeable when used for toothache relief or dental procedures.
The pain that returns often has a throbbing quality and seems worse for a short time. But typically that wears off.
There are neurological problems called channelopathies.
This link has a list of them with sodium included:
http://en.wikipedia.org/wiki/Channelopathy
If you have a genetic error in this process, you most likely would have problems with drugs that affect certain ion channels.
This is pretty difficult to tag by doctors, so may go undiagnosed for a long time or forever in some patients.
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Weezie looking at petunias 8.25.2017
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