I used to take Amitriptyline for bladder pain years ago and it worked great. I was on it for 7 years and never had to increase the dose (50 mg at night). It did have horrible side effects at first. I started it at 5 mg. and increased upt to 50 mg. over a period of several months, which helped alot. The side effects do go away, and for me even the consitipation did too.