Well, Effexor is a mixed acting anti-depressant, and those have shown better effects centrally for chronic pain. Effexor is less toxic to the liver than Cymbalta. But it has norepi effects which are stimulating and even may raise blood pressures.
Some ideas:
1) change or lower the dose of Effexor slightly. The norepi effects may be stimulating you too much. Change to immediate release over long acting, since Effexor has a short half life in the blood.
Don't take it before bedtime.
2) Switch to amitriptyline... this drug has shown usefulness too, and also shows nerve growth potential peripherally.
If you don't sleep, you don't heal, and things get worse over time painwise.
So you need to discuss with your doctor what can be done.
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Weezie looking at petunias 8.25.2017
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