Yes, they can.

I don't know what you have been on, or whether it is for PD or a related problem.

My experience over several drugs taken for a single related problem is that there are withdrawal issues, which include irritability, pain, mood, concentration, etc. These eventually even off, and I feel a lot better.

Trouble is not being able to do without them in the long term.

Do everything you can to relax in the least stressful environment you can find!

Lindy