I have had a very poor response to local anesthetics ever since I remember myself. to the extent that I prefer to have dental work without it, as if at all, it starts working long after I have left the dentist's office, causing numbness of my tongue, but nothing else.

No one seems to understand why that is. I have a neurologist friend who tried to find some connection with my unusual MG. she thought it may be related to sodium channels in some way. she even wanted to do some more sophisticated tests on me, but I never perused it any further. her idea of doing all kinds of nerve conduction tests, while I am given various types of local anasthetics, and seeing how it correlates with my pain threshold, in a very scientific way was not very appealing to say the least.