Laura

I like your wording, "cautioning in general about therapies targeting alpha-synuclein because we do not fully understand its role." That's' what makes me fear gene therapy! Especially using viral vectors (sorry Carolyn ). We cannot fully understand the role of a virius - and past research with viruses haven't been so positive.

Having let researchers put stuff in my head that had never been used in humans, I'm not a good one to give advice, but think about this. I see science putting nearly all of their eggs in one basket - it's almost as if it's the fashionable wave of the month to use new therapies of dopamine replacement (paste - cell transplants - stem cells, etc). Then for the last 4-5 years, researchers are using more and more viral vector delivieries of growth factors, and other "stuff." Heck, it's not been that many years that we have even been studying genetics using DNA and the human genome project.

Am I being too cautious?
Peg