what you mean by pitting edema. As you know, I have been on Lyrica since April 2006 and I do not have any edema. The doctor checks me regularly for this. I am gaining some weight, but at this point, I am thinking it is because I am not outside and not near as active as in the summer. My husband and I do walk at the mall, but sometimes weeks will go by when we don't. We need to start walking on a consistent basis to get ourselves ready for summer and yardwork. Once I get outside, I hope to lose the pounds I have put on (~5-8). If not, then I will investigate if it is the Lyrica. I did not have this problem last summer. In fact, I lost almost 20 pounds from April-November. So....time will tell.