I had the exact same problem with the tops of the thighs. The nurse at my neuro's office suggested I use the sides so now I rotate around using both the insides and outsides of the thighs. I also adjusted the depth on the auto-inject so I'm going a tad deeper - that seems to help with the big lumps that used to appear. I wish I could inject in my stomach every day - that's the easiest area...sounds like it's true for other people as well. It's all trial and error really...this summer I will have been on C for 2 yrs...it does get better. I'm really hoping my MRIs look good so I can stay on it - I've been tolerating it very well and I really don't want to mess around with the side effects of the other drugs...Good luck everyone!