This doesn't pertain to PN exactly, but I was wondering what some of the more physiologically-chemically-molecularly astute people on here would have to say about bisphosphonates, such as Fosamax.

What I am wondering is.....Since bone is metabolically 'active'....that is, alive tissue that is exchanging chemicals with the blood stream, doesn't turning it into a what is essentially a synthetic alter our bodily metabolism? I am not directing this question at the known issues such as jaw necrosis or femoral fractures, but, more at the molecular issue.

It seems to me, that the drugs basically turn bone to stone. Making bone harder does not make it stronger.

I get really nervous when I see a lot of litigation surrounding a drug and it is given out as protocol. (I started on low dose prednisone, bone density now is normal). I am wondering at what point a 'prevention' or 'cure' is worse than the option. This stuff can cause atrial fib, esophageal erosion or cancer even...not to mention the other bone issues.

This was developed as a 'bone cancer' drug, from what I can see and it then became the cure all for any one with bone issues, now a 'preventative'? Eh, call me skeptical. Is this more marketing hype? It is going to take a lot of convincing to get me to swallow this one.