I am hoping MrsD cruises thru this post and helps me a bit here....but I am entertaining all opinions and explanations.

When bisphosphonates are taken, and they 'kill' osteoclasts, do the osteoblasts replace bone with the normal amount of calcium or does actual bone composition change? I mean, is the resultant tissue, still metabolically active bone, or something else?

I have read that after IV bisphosphonates are given, there can be a huge release of T cells in some people.

I am just curious, outside of the bone issues, wouldn't all this affect your body's calcium metabolism for the duration of the drugs action? Would this not also affect other functions where calcium is key? (Yep, most of the body, since Ca is the mainstay of connective tissue).

Am I crazy to be so paranoid of this idea given I am living in a body with substantial autonomic dysfunction including 'autonomic storms' and no one seems to really know what is causing all this?