I wonder if a-synuclein, now known to misfold into pore like structures is deposited within the membrane by cleavage of a larger transmembrane protein, and in this position, in this form acts as an " synthetic ion channel" which "bleeds" or "chokes" the normal ion transfer of Ca, Na, or K, in and out of the cell. This would foul up the normal ionic intra-cellular cytosol ion balance, and possibly trigger apoptosis.
any ideas about this? cs