Hi, I'm a new guy to the forum.

Re: Betaseron & Avonex - my wife started with Beta in '94 when it came out. It seemed to work; however, she had severe injection site reactions and switched to Avonex when it became available. Good news is that not everyone gets the injection site reactions from Beta. Unfortunately my wife still has scars 12 years later.

Avonex reactions - There is a "little secret" for those who are new to Avonex. Avonex originally came out "unmixed", two vials, one powered, one clear solution that you mixed at the time of the injection. The current version of Avonex is "premixed". Unfortunately, some patients, including my wife get noticeable reactions from the premixed version but NOT from the unmixed. I do not believe you can get the mfg to confirm that some people react differently to the pre/unmixed versions; HOWEVER, your doctor can prescribe the unmixed version and it is still available!!