Thread: Scientists Produce First Known Neuroprotective Compound for Parkinson's
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Old 02-14-2011, 08:49 AM
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jeanb jeanb is offline
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Join Date: Aug 2006
Location: sonoran desert
Posts: 1,352
15 yr Member
Lightbulb CEP-1347 was kinases inhibitor
Quote about the CEP-1347 molecule before it went into human clinical trials (~2000):

"Neurons undergoing apoptosis can be rescued by trophic factors that simultaneously increase the activity of extracellular signal-regulated kinase (ERK) and decrease c-Jun N-terminal kinase (JNK) and p38. We identified a molecule, CEP-1347 (KT7515), that rescues motoneurons undergoing apoptosis and investigated its effect on ERK1 and JNK1 activity."

http://www.jneurosci.org/cgi/content/short/18/1/104

The CEP-1347 (PRECEPT) clinical trial 2002-2005 was a kinases inhibitor that showed great promise - in animal studies it protected and also rescued existing neurons. CEP-1347 - a small molecule - was taken orally (it DID pass the BBB). Unfortunately it failed in humans.

Here is wishing for success for this new molecule.

Jean
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Jean B

This isn't the life I wished for, but it is the life I have. So I'm doing my best.
Last edited by jeanb; 02-14-2011 at 05:52 PM. Reason: clarity
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