Debra, I'm glad it worked.

Since Tramadol INHIBITS the acetylcholine receptors, again, I have to wonder if going off of it gives you an "influx" of more acetylcholine. So maybe it isn't not enough acetylcholine when you withdraw but too much.

Get a copy of the ABG they did so that your doctor can assess if it's from a cholinergic (too much) situation or a lack of acetylcholine situation.

This is a very important distinction to determine. If you get too much acetylcholine by going off of it, Mestinon would make that worse. If you are not getting enough, Mestinon, of course, would make that better.

I have no idea which it is. I hope you will give your docs that info about what Tramadol does to acetylcholine!

Annie