I am wondering if it is possible to persuade more friendly bacteria to stay in the get by doing a cleansing enema and then introducing a good liquid probiotic into the colon by way of enema and holding this as long as possible....it is worth a try. I have suffered alot from constipation ever since my diving accident in 7th grade (when my foot turning fist appeared) seems it has been my lot ever since. I for one am goiing to try this and will let you know if there is any noticable change for me.