Yes, several.

Earlier this morning I posted (on the Medications & Treatments board)
http://neurotalk.psychcentral.com/thread145455.html
a quote from an article that states the way gabapentin and similar drugs work is to halt new synapses from forming. Since synapses are the nervous systems communications relays & connections, what you postulate about commanding nerves seems to make sense - to me, anyway.

I've felt similar feelings at different times - that I was getting weaker/sicker and rapidly going downhill. Changing dosages of different meds has definitely helped. One example would be the lighter "as needed" doses of gabapentin that work for me (which have been none since starting R-Lipoic last week).

One of the tenets of medicine is to use the smallest dose of any medication necessary to achieve the desired effect/goal, which requires titration & monitoring. With as many drugs as we have in today's pharmocopia, this is not always practical (for doctors) so they rely upon guidelines provided by drug companies and other sources which have ostensibly been determined by studies & trials on large numbers of patients & controls. But these are still guidelines*, and since everyone is different, it's up to the patient, as advocate, to report findings to their doctors and assist in establishing their own individual regimens.

I had more, but it's slipped away.... probably due to some side effect....

Doc

* I have often likened drug dosage guidelines to dogfood guidelines. These companies are in business to make money by selling product, and their guidelines seem to contradict the "smallest dose necessary" tenet. If I fed my dog what it says to on the bag, I'd be buying dogfood twice as often as I do, and my dog would be morbidly obese. Purdue Pharma was fined millions for marketing Oxycontin in such a way that more was being prescribed than necessary.
http://tinyurl.com/66gxa9l