Originally Posted by glenntaj

--for the maximums that most doctors will prescribe regarding Neurontin (gabapentin) and Lyrica (pregabalin).

Nevertheless, I know of exceptions, among them people with Central Pain/Thalamic Syndrome (common among MS and stroke patients) who've gone higher--one I know of went to 7200mg Neurontin and was still getting slightly increased pain relief after ramping up to that point and was still functional.

For most people, the effect of these meds has a downward slope after about 2400-3000mg of Neurontin, 350-400mg Lyrica or so, in that increasing dosage after these levels by a set amount has less of a therapeutic effect than it did at lower dosages--for example, more effect is felt in going from 1800 to 2400mg Neurontin than in going from 3600-4200mg. There seems to be a diminishing returns curve in absorption ability for most.

Everyone is an experiment of one, though.