--who've reported that for Lyrica, Neurontin, Topomax, and a whole lot of other anti-seizure drugs, that they worked well early on as the dose was being ramped up, but some degree of tolerance occurred after having been a on a stable dose for some time.

This is not unusual--it happens with many meds, as the body "upregulates" its responses to adjust to the drug action. It's also the reason why quitting meds "cold turkey" is generally not advised--that upregulated body action often results in withdrawal symptoms as the body is forced to "downregulate" too rapidly for easy adjustment.

Some people have said, though, that when they experienced this tolerance, switching to a related med helped, or adding a new med while slowly ramping down the original one helped, and then, after a period of "rest", starting the original med back up at a lower dose gave them a greater effect than the one they had gotten used to. Some people even go on med "holidays" for this effect, though they have to get through the period of reduced med levels and, often, symptom increase for a while.

But hey, we're all experiments of one. (I know I say that a lot, but no two people seem to have the exact same reaction to anything. Except, maybe, cute kittens and puppies.)