Truman, My worst side effect has been gastro-intestinal. After being off the full dose of mestinon for approx a year due to side effects that my lovely neuro would not help with I felt I needed to make a stand nomatter what. I went to my pulmonologist and asked if he would do my pulm lab testing before and after a dose of mestinon. I took 15mg and not feeling enough to be sure of success I took another 15mg 30mn later. The 2nd test was next. It was huge. The test that shows how the diaphragm is functionging changed by 50 points! We left to go home and on the interstate I had to have my duaghter pull over so I could vomit. This was from the mestinon. It hit me again when we got back into town about 20mn later, another pull over to vomit in the gutter. It is a violent vomit too. I have had this level of violence in my bowels from it too. Excruitating pain that hits hard and fast and once lasted for 2 hours while the mestinon whore off.

I have to add that I am discovering that some thing I suspected is turning out to be true. The fact that I was vitamin D deficient was affecting how my body responds to mestinon. I have had my 3rd 50,000 dose of vitamin D and as of last 2 days I have been able to take 15mg doses with no problem whatso ever (I am still taking my Lortab prior to dosing.) At some point I will try to take it without Lortab. For now I just need the stability of those higher doses.

I if there is any chance you could be deficient in you D I would explore that. The low vitamin D is a hormone and affects parathroid hormones. I am not a doctor but there is something here for me. It is hard to find an Endo that really knows this area. Even at the university here all but one are specialized in Diabetes. The one I have now switched to does have bone interest so I hoped she would think outside the box. She was gonna do these 50,000k pill with fluids first as my D toleration is very poor. But another doc vetoed it. That was a year ago. Now this neuro I see locally fights deficiency himself so he gets it IS a big big deal so he set it up right away. To me this is a minor miracle.

Annie59

PS. Sorry I didnt see this thread name was already going from AnnieB3. My vision and head have been alot worse along with general other. I havent been here cause of that and reading is far harder tahn ususual..