Thanks Rev - I started out with 1 25/100's 3 times a day - now I'm up to 25/250 2 times a day and sometimes on a bad day I take one before bedtime.

1. No clenching that I'm aware of. The sinemet helps. I also believe that my lack of handling my stress is a factor and after reading your posts it appears to be true of me. A lot of changes in my life the past 3 years.

2. As mentioned my wellness DR thought the inflammation could be there and she put me on some pharma grade CO10 1,000 mg a day along with Neuroflam 2 weeks ago - I have since stared taking tumeric - heard that could help and tart cherry juice concentrate and apple vinegar cider. Been trying to avoid foods that may aid in inflammation and taking more foods/supplements that could aid in suppressing inflammation.

While I am here - I last upped my dosage from 25/100's to 25/250's back in Nov. and it helped - also was real low in vit D and have upped that and both appeared to really make a difference but now I am afraid the sinemet may not be doing the job like it used to or there is something else going on - MY FEAR? How much sinemet can one take till there comes a time where I'm maxed out, if that is possible? - I fear there will be a day when my dosage will be real high and nowhere else to go!

Any thoughts on the potential high dosages?
BTW - no tremors at all - just stiffness and pain. Balance is ok - brain fog better than it used to be once I got off of sleeping pills

Thanks,
God bless