Hi -- I may be going off Tysabri soon and switching to Gilenya. If I do I will be off it for 60 days (which I do anyhow since I get it every other month). Then on day 60 I will have 1,000 mg. of steroids IV and on day 90 I will start Gilenya. The steroidS are a safety measure to prevent relapse or the rebound effect. I always thought that copaxone took several months to kick in and work. Good luck! Keep us posted.