I have not used ACTH.

ACTH has been used since 1978, it's not a new drug but has been used for many years to treat exacerbations. IVSM is the main choice any more for exacerbations but I have read of others who have gone the ACTH route with success.

ACTH and oral prednisone were my only options when I was dx'd in 1985. At that time my neuro only used ACTH for progressive types of MS or those who were not helped by oral prednisone.

Some information about ACTH:
http://www.nationalmssociety.org/abo...cth/index.aspx