I was at a conference in Sarasota where the person from the Cleveland Clinic that did the study gave his presentation. I recently bought a spin bike and ride it daily at 20 mph. This is as close as I can get to forced exercise since you must continuously pedal. I set the resistance to wear I am at 75% target heart rate at the peak of my workout. So far seems to help, either placebo or not I am off less. Go figure??>>