One thing that dapsone causes in the body is a form of anemia, called methemoglobinemia:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1368303/
http://emedicine.medscape.com/article/815613-overview
This changes the heme in blood to Fe+++ which then cannot carry oxygen to tissues. This may be a main cause of the neuropathy... a lack of oxygenated blood.
This link states that some agents used have no "proven" value, but I think they may be worth a try:
http://emedicine.medscape.com/article/815613-treatment
Quote:
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Investigational agents and therapies have no proven benefitsin the treatment of methemoglobinemia (eg, vitamin C, an antioxidant, and N- acetylcysteine, a cellular antioxidant)
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If you no longer take this drug, using the treatment protocols probably are not going to help. (methylene blue, and cimetidine). What I gather is that you no longer take dapsone.
I would do the supplements used to repair myelin:
Omega-3 fatty acids
B6, folate and B12
Using 500mg of Vit C a day can't hurt.
And I'd try the acetyl carnitine + lipoic acid, that support the mitochondria where energy is created in the cells.
The NAC which is n-acetyl cysteine is optional, and is mostly for liver metabolism. If you no longer use the dapsone, I don't know if this is really necessary.
I found one paper suggesting Vit E for dapsone induced neuropathies. Since Vit E is easy to tolerate and is an antioxidant as well, it may be helpful for you. I would choose a form that is natural, and which lists the various types included in it...including gamma E.
example:
Quote:
Vitamin E
(as unesterified d-alpha Tocopherol plus Mixed Tocopherols: d-beta, d-delta and d-gamma Tocopherol)
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note that --ol is in the spelling
from
http://www.iherb.com/Now-Foods-E-400...tgels/304?at=0
I wouldn't go over 1000IU daily, and perhaps 800IU would be enough.
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Weezie looking at petunias 8.25.2017
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