It's really best to just delete them.
replying just verifies that yours is a active email address.

Unless a friend/family member sent it to you and doesn't realize that it just helps all the spammers get more names & email addresses...

I had to explain to my niece that these were mostly made up by spammers /scammers to collect information.

she was sending all these fwds about blessings & orphans , soldiers..
and leaving all the other emails on the top showing to everyone..
she's very trusting & honest and just didn't think that those sweet messages could be some fake scam.