Well if 50 grams works for you, then maybe you really need it that high.

I don't feel comfortable with that high dose, because of that link, and also because high use of ribose may increase uric acid in the blood, and cause gout. This was mentioned in that link too, and also in this one:

http://chronicallyme.wordpress.com/2...make-you-sick/

Gout is very sneaky. In fact I think my ankle which has been bothering me alot for months may be gout, because of the reduced blood flow I have in it from the previous surgery.
My doctor agrees, and I have a slip for blood work, which I will take in next week to the hospital for testing.
You can have high levels of uric acid and no gout attacks, for a long time and boom... then you get one. So increasing uric acid in people with this tendency (some drugs like diuretics cause it too) is really not safe here either.

At the doses I used, I found a steady slow improvement with time. Perhaps taking more will give faster results, but once you are up there where you want to be, I'd consider slowing down on the ribose some, to a steady state lower maintenance amount. There are no studies on chronic use...but I suspect the systems get saturated over time, and the high amount may no longer be necessary. (unless you are building new muscle at a fast rate).

Keep in mind I don't have blood work on people here in front of me like a doctor would, to guide advice. I give conservative advice, and let the readers decide for themselves. That means it becomes YOUR responsibility to choose whether to take something and how much. Many people tolerate high doses of things that others can't. It is really impossible on the net to predict who is who.

I do think you understand that.