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Old 03-22-2011, 12:51 AM
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mrsD mrsD is offline
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

That seems to be a good synopsis in general.

Gout or elevated uric acid levels is a genetic defect as far as I know. Primary uric acid level increases are due to a defect in metabolizing purines.

Secondary uric acid elevations can come from sudden purine flooding the system, which can occur during chemotherapy for leukemias. The elevated white blood cells die at a rapid rate and flood the enzymes so they cannot remove the uric acid produced quickly enough, so gout may occur in a person who does not have the genetic defect. Usually treatment which is temporary, helps this, and is discontinued when the chemo is over.

Some people who are borderline with uric acid problems can have gout attacks when getting over infections. During infections, white cells increase, and then are metabolized away after. This can initiate a gout attack in some people.

I don't think changing food intake has been found to be helpful for gout patients. In the old days, avoidance of rich foods and alcohol were advised. Even Legumes were to be avoided. But now it is pretty well accepted that gout is an internal disease and not that responsive to diet.

Gouty arthritis may also be called pseudogout...and involves calcium rather than uric acid. It presents as "gout" but it is not really because there is not the corresponding elevation of uric acid.

I really don't think the fruit thing is effective enough for genetic uric acid elevations. But it might help with pseudogout.

Typical treatments may include potassium citrate to change pH of the urine, or sodium bicarbonate. These may be more effective than fruit intake.

What bothers me is that ribose is not plentiful in foods. If our bodies were primed (evolved genetically) to need this sugar in large amounts, we'd see it in more food sources. It is present in riboflavin, Vit B2.
But even then intake of this vitamin is quite low.

When we take substances in mega amounts, we have to be very careful.
This concern has also been watched for B12 ...but research has been done on that, showing no toxicity in large doses. I don't think we have the same level of studies on ribose. So some caution should be followed.

Many bodybuilding sites, recommend huge amounts of supplements and high doses of some. Creatine is one. That one also remains controversial. Building muscle rapidly is different from maintaining a body type.

So please be vigilant if you have any side effects down the road with the ribose in high doses. Maintain good hydration also.

Next time you visit the doctor, you can request a uric acid level blood test. That should show if you have a potential for gout.
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Nervous (03-22-2011)