I have HMS , and neuroapthy , i cant say it worsens when my joints are worse , but then my case is not typical so probably useless to you.

I have found some reliefs using supplements suggested by the like of MrsD and others here over the years but I tend to find sometimes - after longer use the effects seem to wear off like nootropics.

I found some relief with rebuilder before it started giving me tinnitus but aside from that only weed ( which was like bliss ) the odd time i tried it.

hope this helps



m