One should test, of course. But few do.
At a minimum: the neurotransmitters, yes, but where? Dopamine in the gut - does it relate to the brain? what about ratios rather than absolute values? Does the level of "x" really matter so long as there is three times as much "y"? So, don't just run into the lab and throw money around. Think it through and have a reason for your decisions.
Don't stop with the brain neurotransmitters, though. In fact, don't even start with them unless you have the reasons. There are other tests that may be of more value to you. For example, There is ample reason to think that PD is driven by inflammation in the CNS. C-reactive protein gives info on the peripheral conditions, but what is going on past the blood brain barrier? Maybe you could learn more by tracking TNF-alpha or another cytokine. Keep in mind that these chemicals are neurotransmitters in their own right, too. We have had the opportunity to observe one of our number go down fast with an abscessed tooth from those chemicals and to bounce back as the antibiotics went to work.
Then there are the similar chemicals of the endocrine system's stress circuits. Cortisol is a reflection of chronic stress, but it is also a reflection of inflammation. Adrenaline is a marker of acute stress, but it can play hell with electrolytes, too. And don't forget the electrolytes! They are responsible for the functioning of both nerves and muscles. Yet, no one tests for them.
Look online and figure out how wide you can cast your net. Maybe you can find a sympathetic GP to give you a break on costs for drawing the specimens.
But share your data here. -Rick
Quote:
Originally Posted by paula_w
Neurotransitter imbalance is responsible for many things, even suspected in ADHD: they just found that multiple sclerosis patients lack norepinephrine. PD patients lack norepinephrine at autopsy as well as dopamine. Our adetylcholine is high when our dopamine is low. IMO it is acetylcholine and glutamate are all major players and highly toxic. Too much of them is why we overfire and we lack gabba. which is responaible for putting on the 'brakes". Serotonin is involed with mental functioning. Dopamine is a precursor to norepinephrine.
So you are on the mark at what you are reading. I have no clue why they do not test for them all. maybe the tests are new. Every pd patient should be tested for this before they start meds. And also for vitamin D.
You are astute and a fast learner. Be sure to let us know what you learn. That's how we do it, but reporting to each other . it is dangerous, for example to assume that a pwp can benefit from Alzheimers meds. especially the youger ones just to improve their memory or focus. THis results in a toxic build up that can paralyze a person.'
Here's a link and please add anything new you can find. I'm requesting to be tested for them at the end of this month - if you find anything else out please let me know.
Your mother is most fortunate to have a problem solver for a son.
http://www.integrativepsychiatry.net...ter_tests.html
sincerely |