Paula, it would be great if it was established exactly what does go haywire when dopamine levels are reduced, and how the other NT's are affected, and what are the signs ........ then we might be able to see exactly what is happening in PD. But I do not see anyone doing this kind of thinking, or not in the scientific world anyway Every one is too busy looking at their own little bit of detail to look at a good overview of NT's ......... we must have all sorts of of compensatory things going on, thats how living things work, by making do with what they have got for as long as possible....