You need to think about this as a wider picture and be aware of other things happening, especially in the dawn period. Cortisol is rising as is insulin. Half a dozen more may play a roll. Your afternoons, by contrast, may be "sedate" as the "tides" pause at the moment of reversal. The day as a whole will affect the response, especially the stress levels. Any infection flareups ditto.

It gets very complicated, but you can gather comparative data from those first hours. What has a better effect as the irst dose? How long does it take to come on and how long does it last? At what point will a second dose of something be needed to sustain a desirable state? It is still messy, but it is as close to a baseline as you're going to get.