I take approximately 1400 mg of sinemet a day - 2 25/100s every 2 hours; 200 mg of amantadine, and nortyriptyline, which i have been given permission to play around with as I'm on a low dose. i am not dyskinetic except around the mouth i'm not sure what's going on there.

i asked my neuro just yesterday about the sinemet dosage and he suggested that it's because i take smaller dosages frequently and my system uses it up before it gets overload. if I were to take 4 every 4 hours i would have dyskinesia. CR is too uneven. Agonists add to the sinemet dose. I don't want that at this point.

I was also relieved to learn that I am at the high end of the recommended range of sinemet dosage.

My neuro quipped, "You certainly are not a moneymaker." All of my medicines are old and they work.