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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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This seems important...
First of all, how could it not be? Second, the antibodies were found in older PWP but not younger?? Twenty years ago....
1. Zh Nevrol Psikhiatr Im S S Korsakova. 1993;93(6):7-11.
[Dopamine antibodies in parkinsonism patients and their possible role in the
pathogenesis of the parkinsonian syndrome].
[Article in Russian]
Man'kovskiĭ NB, Karaban' IN, Kryzhanovskiĭ GN, Evseev VA, Magaeva SV, Vetrila LA,
Trekova NA, Basharova LA, Golubev KM.
Dopamine antibodies (DAb) were found in the blood serum of parkinsonian patients,
middle-aged and elderly, but not young. There was a correlation between the DAb
incidence and dominant symptom in the middle-aged and elderly patients and
between DAb and anginal parkinsonism in the elderly patients. DAb-binding serum
gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced
the pathogenetic mechanism of Parkinson's syndrome (the generator of
pathologically enhanced excitation-GPEE) in this brain part and evoked main
parkinsonian symptoms (oligokinesia, rigidity and tremor). This effect was more
expressed in the elderly rats compared with the young animals. The DAb role in
the Parkinson's syndrome pathogenesis and in L-DOPA therapeutic tolerance
formation is discussed.
PMID: 7512781 [PubMed - indexed for MEDLINE]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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