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DR. MARTHA HERBERT: The brain and the immune system and the gut are intimately related. The cells in those systems have common features. They work together seamlessly, and when you disregulate one, you disregulate all the others. And systems biology is a way of looking at how we work as an integrated whole. I think that's 21st century biology. Is the brain miswired, or is it misregulated? And I've come to think the brain is misregulated. And there are several reasons for that. Short-term, dramatic changes in the functional level of people with autism. One of them is the improvements you see with fever. A child who gets a fever will start to make eye contact, be interactive, will relate. A child who would have been really out of touch will become connected, and then it will go away.
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And systems biology is a way of looking at how we work as an integrated whole. I think that's 21st century biology. Is the brain miswired, or is it misregulated?
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DR. MARTHA HERBERT: I think it's possible that you could have a genetic subgroup. You also might have an immune subgroup. There are a variety of subgroups. But the problem with the population studies is they don't they aren't necessarily designed to have the statistical power to find subgroups like that if the subgroups are small.
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http://www.pbs.org/newshour/bb/healt...ses_04-20.html
PBS News Hour: REPORT AIR DATE: April 20, 2011
Autism's Causes: How Close Are We to Solving the Puzzle?